Rapamycin (sirolimus) is prescribed off-label for longevity optimization at low doses. This is not FDA-approved for aging/healthspan. Compounded rapamycin is prepared by a licensed pharmacy. Physician supervision required.
Rapamycin (sirolimus) is an mTOR pathway inhibitor originally developed for transplant immunosuppression. At low weekly doses, it has become the focus of significant longevity research—and the only drug shown to extend lifespan across multiple mammalian species.
Published research demonstrates rapamycin's effects on cellular aging, autophagy activation, senescent cell reduction, and metabolic health. The weekly low-dose protocol avoids the immunosuppression risks seen at daily therapeutic doses, while unlocking mTOR-related longevity benefits.
At Obsidian Genetics, we offer physician-supervised low-dose rapamycin protocols tailored to healthspan optimization—one transparent monthly price, personalized dosing, and ongoing provider oversight.
Includes ongoing provider care & support
Compounded medication · Platform access
From landmark aging biology and lifespan extension studies.
Research citations reflect published preclinical and clinical studies on rapamycin's longevity mechanisms. Off-label longevity use in humans is not FDA-approved. Lifespan extension demonstrated in animal models; human longevity outcomes remain to be established. Individual health outcomes may vary. Physician oversight required.
All applications reflect emerging longevity research. Off-label use is not FDA-approved and requires physician evaluation and monitoring.
Initial evaluation to determine if low-dose rapamycin is appropriate for you, including full health history review and longevity goal alignment.
Your provider establishes your starting dose (typically 1–2mg weekly) and adjusts based on your response and lab work—all included, no extra fees.
High-quality rapamycin prepared for low-dose weekly administration. Discreet, confidential delivery to your home with temperature control.
Baseline and ongoing CBC, metabolic panel, and lipid monitoring. Your provider reviews labs and adjusts your protocol as needed.
Regular check-ins, dosing guidance, and direct access to your physician throughout your longevity protocol—for the long term.
mTOR inhibition. Rapamycin binds FKBP12 and inhibits mTOR Complex 1 (mTORC1)—the nutrient-sensing hub that drives aging-related growth and proliferation.
Autophagy activation. mTORC1 inhibition triggers autophagy—the cellular "cleanup" process that removes damaged proteins, mitochondria, and senescent debris.
Longevity benefits. Weekly dosing preserves mTORC2 function (immune health) while capturing mTORC1 aging-suppression benefits—the "sweet spot" for healthspan.
Rapamycin is a prescription medication. Off-label longevity use requires physician evaluation and oversight. Not appropriate for all patients.
Do not use rapamycin if you have: active infections, pregnancy (teratogenic), known hypersensitivity to rapamycin or sirolimus, or uncontrolled immunosuppression. Rapamycin is not recommended with live vaccines. If you have a history of severe infections, impaired immune function, or kidney disease, discuss with your provider before use.
Important: Rapamycin (sirolimus) is FDA-approved as an immunosuppressant (Rapamune). Off-label use for longevity and healthspan optimization is not FDA-approved and is prescribed by licensed providers at their discretion. Compounded rapamycin is not an FDA-approved drug product and has not undergone independent FDA review for safety or effectiveness. This is a cutting-edge longevity protocol—clinical evidence is promising in preclinical models, but human longevity trials are ongoing and definitive human lifespan extension data does not yet exist. A licensed Obsidian Genetics physician will evaluate your full health history and determine whether low-dose rapamycin is appropriate for you. This product requires a prescription from a licensed healthcare provider. Prescription required. Individual results vary. Research statistics cited reflect published studies on rapamycin's mechanisms in aging biology—human longevity outcomes have not been independently verified. Always disclose all medications, supplements, and health conditions to your provider. Do not use if you are pregnant, have active infections, or known hypersensitivity to rapamycin. Lab monitoring is mandatory. Rapamycin may interact with certain medications and supplements—discuss all treatments with your provider before starting.